KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs953088090
rs953088090
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE KRAS E63K is curated in the Catalogue of Somatic Mutations in Cancer database. 31289513 2019
dbSNP: rs953088090
rs953088090
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.010 GeneticVariation BEFREE KRAS E63K is curated in the Catalogue of Somatic Mutations in Cancer database. 31289513 2019
dbSNP: rs8720
rs8720
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.010 GeneticVariation BEFREE <b>Materials & methods:</b> The rs8720 and rs7960917 in <i>KRAS</i> 3'UTR for colorectal carcinoma</span> (CRC) risk and survival were investigated in a case-control study. 31729889 2020
dbSNP: rs7973450
rs7973450
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C4086165
Disease:
Childhood Neuroblastoma 		0.010 GeneticVariation BEFREE Overall, our results suggested that rs7973450 A>G was associated with increased neuroblastoma risk. 31564912 2019
dbSNP: rs7973450
rs7973450
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0027819
Disease:
Neuroblastoma 		0.010 GeneticVariation BEFREE Overall, our results suggested that rs7973450 A>G was associated with increased neuroblastoma risk. 31564912 2019
dbSNP: rs7973450
rs7973450
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0700095
Disease:
Central neuroblastoma 		0.010 GeneticVariation BEFREE Overall, our results suggested that rs7973450 A>G was associated with increased neuroblastoma risk. 31564912 2019
dbSNP: rs7960917
rs7960917
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.010 GeneticVariation BEFREE <b>Materials & methods:</b> The rs8720 and rs7960917 in <i>KRAS</i> 3'UTR for colorectal carcinoma (CRC) risk and survival were investigated in a case-control study. 31729889 2020
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		A 0.700 CausalMutation CLINVAR Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. 19114683 2009
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. 20921465 2010
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. 21228335 2011
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		A 0.700 CausalMutation CLINVAR Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. 21228335 2011
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		A 0.700 CausalMutation CLINVAR KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. 16618717 2006
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0278701
Disease:
Gastric Adenocarcinoma 		G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C2239176
Disease:
Liver carcinoma 		G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. 20921462 2010
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. 16618717 2006
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.700 GeneticVariation UNIPROT
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		A 0.700 CausalMutation CLINVAR Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. 16361624 2005
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0152018
Disease:
Esophageal carcinoma 		G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. 19114683 2009
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		A 0.700 CausalMutation CLINVAR Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. 20921465 2010
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. 18316791 2008
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0151779
Disease:
Cutaneous Melanoma 		G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs770248150
rs770248150
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease:
Colorectal Neoplasms 		G 0.700 CausalMutation CLINVAR Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. 16361624 2005